Progress on three-dimensional cell culture technology and their application / 生物医学工程学杂志

Three-dimensional (3D) cell culture model is a system that co-culture carriers with 3D structural materials and different types of cells in vitro to simulate the microenvironment in vivo. This novel cell culture model has been proved to be close to the natural system in vivo. In the process of cell attachment, migration, mitosis and apoptosis, it could produce biological reactions different from that of monolayer cell culture. Therefore, it can be used as an ideal model to evaluate the dynamic pharmacological effects of active substances and the metastasis process of cancer cells. This paper compared and analyzed the different characteristics of cell growth and development under two-dimensional (2D) and 3D model culture and introduced the establishment method of 3D cell model. The application progress of 3D cell culture technology in tumor model and intestinal absorption model was summarized. Finally, the application prospect of 3D cell model in the evaluation and screening of active substance was revealed. This review is expected to provide reference for the development and application of new 3D cell culture models.

Arthroscopic Repair of Rotator Cuff Injury: An Analysis of Function, Muscular Strength and Pain Between Single Row and Double Row Techniques / Reparo artroscópico da lesão de manguito rotador: Uma análise da função, força muscular e dor entre técnicas de fileira simples e fileira dupla

Abstract Objective To evaluate the patients submitted to arthroscopic repair of the rotator cuff (RC), comparing the functional results, muscle strength, and pain obtained after single row (SR) and double row (DR) techniques. Methods Data were collected at the postoperative follow-up (minimum of 12 months) of 128 patients submitted to arthroscopic RC repair from 2011 to 2018. The clinical-functional variables were collected through the clinical examination, and the demographic, surgical and injury variables of the RC were collected from the electronic medical records. The results were compared between the SR and DR groups. Results The DR group showed higher anterior elevation strength when compared with the SR group (SF: 4.72 ± 2.73 kg versus DR: 5.90 ± 2.73 kg; p = 0.017). The other variables of muscle strength, Constant-Murley Score, University of California at Los Angeles Shoulder Rating Scale (UCLA), and pain, were similar. Performing the stratification by size, in the analysis of small and medium injuries, no differences were found between the groups. However, in the analysis of large and extensive injuries, patients submitted to DR presented superiority of both muscle lifting strength (SF: 3.98 ± 2.24 kg versus DR: 6.39 ± 2.73 kg) and Constant score (SF: 81 ± 10 versus DR: 88 ± 7). Conclusion The use of the DR technique in arthroscopic RC repair allowed higher levels of muscle strength for anterior shoulder elevation when compared with the SF technique. Data stratification in large and extensive injuries showed superiority of anterior shoulder elevation muscle strength and of the Constant score in patients submitted to DR.

Resumo Objetivo Avaliar os pacientes submetidos ao reparo artroscópico do manguito rotador (MR), comparando-se os resultados funcionais, força muscular e dor obtidos após as técnicas de fileira simples (FS) e de fileira dupla (FD). Métodos Foram coletados os dados do seguimento pós-operatório (mínimo de 12 meses) de 128 pacientes submetidos ao reparo artroscópico do MR durante o período de 2011 a 2018. As variáveis clínico-funcionais foram coletadas por meio do exame clínico, e as variáveis demográficas, cirúrgicas e das lesões do MR a partir dos prontuários eletrônicos. Os resultados foram comparados entre os grupos FS e FD. Resultados O grupo FD demonstrou força de elevação anterior maior quando comparado ao grupo FS (FS: 4,72 ± 2,73 kg versus FD:5,90 ± 2,73 kg; p = 0,017). As demais variáveis de força muscular, Constant-Murley Score, University of California at Los Angeles Shoulder Rating Scale (UCLA, na sigla em inglês) e dor foram similares. Realizando-se a estratificação por tamanho, na análise das lesões pequenas e médias, não foram encontradas diferenças entre os grupos. Porém, na análise das lesões grandes e extensas, os pacientes submetidos à FD apresentaram superioridade tanto na força muscular de elevação (FS: 3,98 ± 2,24 kg versus FD: 6,39 ± 2,73 kg) quanto no escore Constant (FS: 81 ± 10 versus FD: 88 ± 7). Conclusão A utilização da técnica de FD no reparo artroscópico do MR possibilitou maiores níveis de força muscular para elevação anterior do ombro quando comparada à técnica de FS. A estratificação dos dados em lesões grandes e extensas evidenciou superioridade da força muscular de elevação anterior do ombro e do escore Constant nos pacientes submetidos à FD.

Several Critical Issues of Low Rectal Cancer Surgery / 肿瘤防治研究

Colorectal cancer is one of the top three malignant tumors in the world. With the rapid development of medical technology and the strengthening of national awareness of cancer screening, rectal cancer has been diagnosed and treated timely. At present, the application of low rectal tumor preservation operation is becoming more and more common. Anastomotic leakage and anterior resection syndrome are the most common complications of low rectal cancer. How to preserve anal and reduce the incidence of complications has always been the concern of scholars at home and abroad. In order to improve the survival time and quality of life of patients with low rectal cancer, this paper expounds five key problems: fully preoperative evaluation of anorectal function and staging, reasonable neoadjuvant therapy, safe distal margin, the selection of surgical methods and the timing of preventive stoma.

Modern therapeutic strategies for submandibular lithiasis / 口腔疾病防治

@#Most salivary gland stones involve the submandibular gland, which often cause recurrent swelling and pain of the glands after meals, and used to be the main reasons for the gland removals. With the trend of minimally invasive treatment, gland preservation and functional recovery in the diagnosis and the treatment of submandibular lithiasis have been paid more and more attention. New equipment and technologies such as CBCT and sialendoscopy, which are widely used in clinical practice, have contributed a lot to the accurate orientation and minimally invasive treatment of stones, and enriched the managements of submandibular lithiasis. Based on our experience and the review of relevant literature, this paper attempts to summarize the treatment strategies for submandibular stones distributed in different parts of the duct: ① emphasizing on the integrity and functions of the organ; ② endoscopy and minimal invasiveness come first; ③ scientific classifications and personal managements. Appropriate treatment options should be selected according to the features of the stones: endoscopic lithotomy helps a lot in removing those located in the anterior or middle part of the duct; endoscopic lithotomy or/and sialolithotomy are needed according to the features of hilar stones; the regular follow-up is required for the intraglandular stones. Meanwhile, the evaluation of the gland function is also important. After the removals of sunmandibular stones, the functions of the glands should be promoted to restore as far as possible.

Functional evaluation after function-preserving gastrectomy / 中华胃肠外科杂志

With the increase of people's health awareness and the progress of medical diagostic technology in recent years, the diagnosis rate of early gastric cancer is increasing year by year. Although radical surgery has good efficacy, how to maximize the preservation of the normal anatomy and function of the stomach and improve the quality of life of patients in the pursuit of radical surgery has become a more important issue in the treatment of early gastric cancer. Under the condition of ensuring radical lymph node dissection, function-preserving gastrectomy can fully preserve gastric function by reducing the resection extent and preserving the pylorus and the vagus nerve, which has advantage of improving quality of life and has great potential in the treatment of early gastric cancer. However, there is no functional evaluation standard for function-preserving gastrectomy at present. Most of the patients are evaluated by quality of life scale, which is relatively subjective. Even though the evaluation of endoscopy, hematology and other objective means can indicate the benefit degree in quality of life brought by functional reconstruction, the evidence level is limited. Therefore, this paper discusses the research status of function-preserving gastrectomy evaluation, postoperative complications, postoperative nutritional status, auxiliary examination and other items in the evaluation of gastric function, and analyzes the prospects of research direction in this field.

Evaluación funcional de un programa de entrenamiento físico en pacientes infartados con disfunción sistólica severa del ventrículo izquierdo / Functional evaluation of a physical training programme in myocardial infarction patients with severe left ventricular systolic dysfunction

Resumen Objetivo: Evaluar la factibilidad y los efectos sobre la capacidad funcional de un programa de entrenamiento físico supervisado, aplicado en pacientes con disfunción sistólica severa del ventrículo izquierdo después de infarto agudo de miocardio. Métodos: Se estudiaron 37 pacientes, de ambos sexos y sin límites de edad, con diagnóstico de disfunción sistólica severa del ventrículo izquierdo, después de haber sufrido un infarto agudo de miocardio, que consecutivamente se incorporaron al programa ambulatorio del Centro de Rehabilitación del Instituto de Cardiología. Se hicieron pruebas de esfuerzo máximas limitadas por síntomas con determinación de consumo de oxígeno, ecocardiogramas en reposo y ventriculografías isotópicas en reposo y esfuerzo a los 2, 8 y 18 meses de evolución, y un tiempo medio de seguimiento clínico de 4,1 años. A todos se les prescribió un régimen de entrenamiento físico moderado o intenso, durante un año como mínimo. Se consideró disfunción sistólica severa cuando la fracción de eyección del ventrículo izquierdo fue menor de 35%. Resultados: Todos los parámetros ergométricos que expresaron capacidad funcional incrementaron significativamente en la evaluación del octavo mes (p< 0,0005), permaneciendo invariables a los 18. La fracción de eyección del ventrículo izquierdo media en reposo inicial fue de 28,3 ± 5,3%, la cual no mostró variaciones significativas con el esfuerzo ni con otros estudios evolutivos. La mortalidad total y la morbilidad de la serie fueron de 10,5% y 47,3%, respectivamente. Conclusión: El entrenamiento físico supervisado en pacientes infartados con disfunción sistólica severa de ventrículo izquierdo fue seguro y efectivo, y mejoró su calidad de vida, sin causar efectos negativos sobre la función ventricular.

Abstract Objective: To evaluate the feasibility and effects on the functional capacity of a supervised physical training programme carried out on patients with severe left ventricular systolic dysfunction after an acute myocardial infarction. Methods: The study included a total of 37 patients, males and females of any age, with a diagnosis of severe left ventricular systolic dysfunction after having suffered an acute myocardial infarction. They were consecutively included into the ambulatory programme of the Institute of Cardiology Rehabilitation Centre. Maximum effort tests, limited by symptoms, were performed to determine oxygen consumption. Echocardiograms were also performed at rest, with isotopic ventriculography at rest and then at 2, 8, and 18 months. The mean clinical follow-up was 4.1 years. They were all prescribed to a moderate or intense training programme for at least one year. Severe left ventricular systolic dysfunction was considered when the left ventricular ejection fraction was less than 35%. Results: All the ergometric parameters that expressed functional capacity increased significantly in the evaluation at 8 months (P< .0005), and remained at 18 months. The initial mean left ventricular ejection fraction at rest was 28.3 ± 5.3%, which showed no significant changes with effort or in the other evaluation times. The overall mortality and morbidity of the series was 10.5% and 47.3%, respectively. Conclusion: Supervised physical training in patients after an acute myocardial infarction and with severe left ventricular systolic dysfunction was safe and effective, and improved the quality of life, without causing negative effects on ventricular function.

Some thoughts on health food formulated with traditional Chinese medicine / 中国中药杂志

The health food industry is an important support for the big health industry and the strategy of healthy China. The Chinese medicine prescription health food has exceeded 60% of the total declared health food. However,the main basis for its function evaluation,the Technical Specification for Inspection and Evaluation of Health Food,was abolished in 2018,and 27 of them were based on modern medical and nutritional theories. Quantitative efficacy evaluation methods in western pharmacology are short of function claims and function evaluation methods reflecting the characteristics of traditional Chinese medicine,which could affect the health food industry to a certain extent. Therefore,the establishment of the evaluation mechanism of Chinese medicine prescription health food which conforms to the positioning of health food and the theory of traditional Chinese medicine is helpful for the healthy development of health food industry. In this paper,this problem was explained from five aspects. First,how to differentiate the positioning of Chinese medicine prescription health food from ordinary food and medicine,and how to embody the characteristics of Chinese medicine. Secondly,the relationship between traditional Chinese medicine prescription health food and Chinese patent medicine. Thirdly,how to scientifically and reasonably determine the raw materials of traditional Chinese medicine prescription health food. Fourthly,how to explain the function claim of traditional Chinese medicine prescription health food,and how to evaluate its function scientifically and reasonably. Fifthly,the functional evaluation of Chinese herbal medicine prescription health food is connected with other national scientific and technological strategies. In this paper,a preliminary analysis of the Chinese medicine prescription health food was conducted from the above five aspects,and some personal views and suggestions were put forward,hoping to provide reference for the competent authorities and researchers.

Características clínicas y radiológicas de una cohorte de niños con trombosis venosa intracraneal / Clinical and radiological features of cerebral venous thrombosis in a children cohort

Resumen: Introducción: La trombosis venosa intracraneal (TVI) es una condición infrecuente y poco estudiada en población pediátrica. Objetivos: Describir y comparar características clínicas/radiológicas de ni ños no neonatos con TVI según edad y analizar la asociación de estas variables con deterioro funcio nal al alta o mortalidad aguda. Metodología: Estudio observacional de una cohorte de niños > 30 días con una primera TVI diagnosticada con imágenes/venografía por resonancia magnética encefálica. Medimos funcionalidad con la escala modificada de Rankin definiendo compromiso funcional mar cado con 3 a 5 puntos. Comparamos los promedios de edades entre grupos con y sin las diferentes variables estudiadas con la prueba U-Mann-Whitney (significancia < 0,05). Realizamos análisis de regresión logística para estimar el riesgo de resultado adverso de cada variable expresado en Odds Ra tios (ORs) e intervalos de confianza (IC) al 95%. Resultados: De 21 pacientes, 42.8% eran niñas, me diana de edad 6,27 años (rango intercuartil: 0,74-10). El promedio de edad fue menor en niños con retardo diagnóstico > 48 h (p = 0,041), puntaje < 12 en la escala coma de Glasgow (p = 0,013), crisis epilépticas (p = 0,041), trombosis de seno recto (p = 0,011) y hemorragia intracraneal (p = 0,049); mientras que fue mayor en niños con síndrome de hipertensión endocraneal (p = 0,008). La presen cia de alguna condición crónica sistémica (OR = 11,2; IC = 1,04-120,4), TVI profunda (OR = 14; IC = 1,3-150,8) e infarto encefálico (OR = 15,8; IC = 1,4-174,2) se asoció a compromiso funcional marcado o mortalidad al alta. Conclusiones: Las características clínicas/radiológicas de la TVI varían según la edad. Las patologías crónicas, compromiso del sistema venoso profundo e infarto encefálico predicen mal pronóstico a corto plazo.

Abstract: Introduction: Cerebral venous thrombosis (CVT) is an uncommon and poorly studied condition in the pediatric population. Objectives: To describe and compare the clinical and radiological features of non-neonatal children with CVT according to age and to analyze their association with functional impairment or mortality at hospital discharge. Methodology: An observational cohort study of chil dren older than 30 days with a first CVT diagnosed with imaging/venography by magnetic resonance (IMR/VMR). We measure functionality with the modified Rankin scale defining marked impairment with 3 to 5 points. We used U-Mann-Whitney test to compare ages averages between groups with and without the different studied variables (significance < 0.05). We used logistic regression analyses to estimate the risk of adverse outcome for each variable expressed in Odds Ratios (ORs) and 95% confidence intervals (CI). Results: Among 21 patients recruited, 42.8% were girls, median age 6.27 years (Interquartile range: 0.74-10). The average age was lower in children with diagnostic delay > 48 hours (p = 0.041), score < 12 in the Glasgow coma scale (p = 0.013), seizures (p = 0.041), sinus rectus thrombosis (p = 0.011), and intracranial hemorrhage (p = 0.049); while it was significantly higher in children with intracranial hypertension syndrome (p = 0.008). The presence of some chro nic systemic condition (OR = 11.2; CI = 1.04-120.4), deep CVT (OR = 14; CI = 1.3-150.8), and brain ischemia (OR = 15.8; CI = 1.4-174.2) was associated with marked functional impairment or mor tality at discharge. Conclusions: Clinical and radiological features of CVT are age-related. Chronic illnesses, deep venous system involvement, and brain ischemia predict adverse short-term outcomes.

Relação dos índices antropométricos e vitamina D com o desempenho funcional em idosos / Relationship of anthropometric indices and vitamin D with functional performance in elderly

A complexidade que abrange o processo do envelhecimento e a saúde do idoso envolve mudanças no estado nutricional, como alterações dos índices antropométricos e das concentrações de vitamina D. Este trabalho teve como objetivo analisar o desempenho funcional dos idosos e sua relação com parâmetros antropométricos e níveis de vitamina D. Trata-se de um estudo transversal e descritivo, realizado com 359 idosos assistidos por equipes da Estratégia Saúde da Família (ESF) do município de Teresina-PI, no período entre fevereiro a junho de 2011. Os idosos foram entrevistados individualmente em visitas domiciliares, utilizando-se um questionário estruturado com questões abertas e fechadas referentes aos dados sociodemográficos. Em seguida, foram submetidos ao exame bioquímico onde se realizou uma venopunção, com uma coleta de 5ml de sangue para posterior dosagens séricas de 25OHD. Logo após, foi realizada a avaliação dos índices antropométricos, por meio de medidas de massa corporal (MC), estimativa da estatura (E), índice de massa corporal (IMC), circunferência do braço e dobra cutânea tricipital. E posteriormente, para a avaliação do desempenho funcional dos idosos foi utilizado o teste Timed Up and Go (TUG). Os resultados demonstraram que o tempo médio de realização do TUG foi 13,8s. Observou-se que massa corporal (12%), altura (6%), área muscular do braço (5%) e vitamina D (29%) foram estatisticamente significativas (p < 0,05) quando comparados entre os sexos. A correlação foi significativa entre associações TUG, idade (p = 0,407, p < 0,001) e altura (p = -0,201, p < 0,001). Foram encontradas correlações significativas entre o TUG, idade (p = 0,413, p < 0,001) e altura (p = -0,259, p < 0,001) para o grupo feminino (n = 220) e correlações significativas entre o TUG, idade (p = 0,507, p < 0,001) para o grupo masculino (n = 139). Conclui-se que dentre os parâmetros antropométricos o IMC e a circunferência abdominal foram associados com o desempenho no teste mostrando que quanto maior o IMC e CA maior o tempo de realização do teste. Os níveis séricos de Vitamina D não foram associados ao desempenho no teste. (AU)

The complexity covering the aging process and the health of the aged involves changes in nutritional status, such as changes in anthropometric indices and vitamin D concentrations. This study aimed to analyze the functional performance of the aged and its relationship with anthropometric parameters and levels of vitamin D. It is a transversal and descriptive study with 359 aged people assisted by teams of the Family Health Strategy (FHS) in the city Teresina-PI in the period from February to June 2011. The aged were interviewed individually during home visits, using a structured questionnaire with open and closed questions relating to sociodemographic data. They were then subjected to biochemical tests were conducted a venipuncture through a collection of 5ml of blood for subsequent serum levels of 25OHD. Soon after, it was carried out the evaluation of anthropometric indices, using body mass (MC), height estimate (E), body mass index (BMI), arm circumference and triceps skinfold thickness. And later, to evaluate the functional performance of the aged was used test Timed Up and Go (TUG). The results showed that the mean duration of the TUG was 13,8s. It was observed that body weight (12%), height (6%), muscle area of the arm (5%) and vitamin D (29%) were statistically significant (p < 0.05) when compared between the sexes. Correlation coefficients were significant associations between TUG, age (p = 0.407, p < 0.001) and time (p = -0.201, p < 0.001). Significant correlations were found between the TUG, age (p = 0.413, p < 0.001) and height (p = -0.259, p < 0.001) for the female group (n = 220) and significant correlations between the TUG, age (p = 0.507, p < 0.001) for the male group (n = 139). It is concluded that among the anthropometric parameters BMI and waist circumference were associated with performance on the test showing that the higher BMI and higher CA the test performance time. Serum levels of vitamin D were not associated with performance on the test. (AU)

Reparación artroscópica con banda simple en pacientes con lesión aislada de ligamento cruzado posterior. Serie de Casos / Single-row arthroscopic repair in patients with isolated posterior cruciate ligament injury. Case Series

Introducción La lesión aislada del ligamento cruzado posterior ocasiona inestabilidad y falla del componente rotatorio de la rodilla. El objetivo del trabajo es describir los resultados del tratamiento artroscópico con banda simple operados por técnica de un solo haz con monotúnel y fijación con tornillos interferenciales en pacientes con lesiones aisladas del Ligamento Cruzado Posterior grado III. Materiales & métodos Estudio transversal. Se utilizó el formulario IKDC para evaluar tratamiento de lesiones del Ligamento Cruzado Posterior preoperatoriamente y al año. La estadística empleada fue descriptiva, se utilizaron medidas de tendencia central y dispersión, U de Mann Whitnney-Wilcoxon para comparar medias. Resultados Fueron 5 pacientes, 4(80%) fueron masculinos y 1(20%) femenino, la edad promedio 27.8 años (mínima 20, máxima 33) ± 5.58 años, el lado afectado fue derecho en 3(60%), izquierdo en 2(40%) pacientes, todos presentaron signo de cajón posterior positivo. Los resultados del formulario IKDC prequirúrgico y al año fueron: diferencia de promedios 2.6, suma de rangos negativos 15, suma de rangos positivos 0, z= -2.070, p=0.038, al año ningún paciente presentó signo de cajón posterior positivo. Discusión El tratamiento de lesiones aisladas del LCP grado III con técnica de un solo haz y monotúnel con autoinjerto de isquiotibiales por vía artroscópica ofrece resultados buenos.

Background Isolated lesions of the posterior cruciate ligament cause instability and failure in the rotating component of the knee. The objective of this article is to describe the results of single-row arthroscopic treatment using a single-bundle technique with a single tunnel and fixation with interference screws in patients with isolated lesions of the Posterior Cruciate Ligament, grade III. Methods A cross-sectional study was conducted using the IKDC Test to evaluate, pre-operatively and yearly, the treatment of posterior cruciate ligament injuries. The statistics used were descriptive, as well as measures of central tendency and dispersion, and Mann Whitney U- Wilcoxon tests to compare means. Results The study included 5 patients, 4 (80%) were male and 1 (20%) female, and a mean age 27.8 years (minimum 20, maximum 33) ± 5.58 years). The affected side was right in 3%, left in 2 (40%) patients, and all showed a posterior drawer sign. The results of the pre-operative IKDC test were: difference of means 2.6, sum of negative ranks 15, sum of positive ranks 0, z = -2.070, P=.038; after surgery no patient had a positive posterior drawer sign. Discussion The treatment of isolated grade III lesions of PCL with a single bundle and tunnel technique with an arthroscopic autograft of hamstrings offers good results.

Perfil de saúde de idosos adventistas que ultrapassaram a expectativa de vida / Health profile of adventist elders who exceeded life expectancy / Perfil de salud de ancianos adventistas que superaron la expectativa de vida

O objetivo deste estudo foi verificar aspectos do perfil de saúde de idosos adventistas do sétimo dia que ultrapassaram a expectativa média de vida. O estudo realizado foi analítico observacional transversal. Participaram da pesquisa 90 idosos com média de idade de 82,9 anos. A coleta de dados consistiu na aplicação dos seguintes instrumentos de avaliação: o mini-exame do estado mental (MEEM), questionário sócio-demográfico para conhecer o perfil social; mini-avaliação nutricional (MAN), e a Escala Internacional de Eficácia de Quedas (FES). As atividades básicas da vida diária (AVDB) foram avaliadas pela escala funcional de Katz e a Escala de Lawton e Brody de atividades instrumentais de vida diária (AIVD). A maioria dos idosos entrevistados era de brancos, casados, com 7,3 anos de estudos, aposentados, filhos de pais longevos e do sexo masculino. A doença mais prevalente foi a hipertensão arterial. A carga de doenças foi de 3,2 doenças. A pontuação na Escala de Katz foi de 6,3±0,8 pontos, na Escala de Lawton e Brody de 25,1±3,8, na Escala FES foi de 24,7±10,4 e na MAN de 11,7±1,3 pontos. Não houve diferença ao serem comparados homens em relação a mulheres. Ao serem feitas as correlações entre as variáveis estudadas, houve muitas correlações significantes, porém fracas. Apenas 4 correlações foram consideradas moderadas. Correlação positiva entre AIVD e MEEM, entre AIVD e MAN, Correlação inversa entre AIVD e FES e AIVD e ABVD.

The objective of this study was to study the health profile of Seventh-day Adventist elderly who exceeded the average life expectancy. The study was transversal observational analytical. A total of 90 elderly people with an average age of 82.9 years participated in the study. The data collection consisted of the application of the following evaluation instruments: The mini mental state examination (MEEM), socio-demographic questionnaire to know the social profile; mini nutritional assessment (MAN), International Falls Efficiency Scale (FES). The basic activities of daily living (BADL) were assessed by the Katz functional scale and the Lawton and Brody Scale of instrumental activities of daily living (IADL). The majority of the elderly interviewed were white, married, with 7.3 years of education, retired, children of long-lived and male parents. The most prevalent disease was hypertension. The burden of disease was 3.2 diseases. The Katz Scale score was 6.3 ± 0.8 points, in the Lawton and Brody Scale of 25.1 ± 3.8, in the FES Scale was 24.7 ± 10.4 and in the MAN score of 11, 7 ± 1.3 points. There was no difference when men from women were compared. When the correlations between the studied variables were made, there were many significant but weak correlations. Only 4 correlations were considered moderate. Positive correlation between IADL and MEEM, between IADL and MAN, inverse correlation between IADL and FES and IADL and BADL.

El objetivo de este estudio fue aspectos del perfil de salud de los ancianos adventistas del séptimo día que sobrepasaron la expectativa media de vida. El estudio realizado fue analítico observacional transversal. Participaron de la encuesta 90 ancianos con promedio de edad de 82,9 años. La recolección de datos consistió en la aplicación de los siguientes instrumentos de evaluación: El mini examen del estado mental (MEEM), cuestionario socio demográfico para conocer el perfil social; minima evaluación nutricional (MAN), Escala Internacional de Eficacia de Caídas (FES). Las actividades básicas de la vida diaria (AVDB) fueron evaluadas por la escala funcional de Katz y la Escala de Lawton y Brody de actividades instrumentales de vida diaria (AIVD). La mayoría de los ancianos entrevistados eran blancos, casados, con 7,3 años de estudios, jubilados, hijos de padres longevos y del sexo masculino. La enfermedad más prevalente fue la hipertensión arterial. La carga de las enfermedades fue de 3,2 enfermedades. La puntuación en la escala de Katz fue de 6,3 ± 0,8 puntos, en la escala de Lawton y Brody de 25,1 ± 3,8, en la escala FES fue de 24,7 ± 10,4 y en la MAN de 11, 7 ± 1,3 puntos. No hubo diferencia al ser comparados hombres de mujeres. Al hacer las correlaciones entre las variables estudiadas, hubo muchas correlaciones significantes, pero débiles. Sólo 4 correlaciones se consideraron moderadas. Correlación positiva entre AIVD y MEEM, entre AIVD y MAN, Correlación inversa entre AIVD y FES y AIVD y ABVD.

Hiperentorno para la enseñanza-aprendizaje de la valoración de la capacidad funcional de miembros superiores / Hyperentorno for the teaching-learning of the assessment of the functional capacity of superior members

Fundamento: Las tecnologías de la información y las comunicaciones pueden ser utilizadas con éxito como medios del proceso de enseñanza-aprendizaje en las carreras de las ciencias médicas. Objetivo: Elaborar un hiperentorno para contribuir a la enseñanza-aprendizaje de la valoración de la capacidad funcional de los miembros superiores como contenido de la carrera Rehabilitación en Salud. Metodología: Se utilizaron métodos del nivel teórico y empírico. La población para la aplicación parcial estuvo formada por cuatro profesores y 22 estudiantes de quinto año del curso 2014-2015 de la carrera Rehabilitación en Salud de la Universidad de Ciencias Médicas de Sancti Spíritus(AU)

Translation and transcultural adaptation of the Hip Fracture Recovery Score assessment tool / Tradução e adaptação transcultural do instrumento de avaliação do quadril Hip Fracture Recovery Score

OBJECTIVE: The Hip Function Recovery Score questionnaire is an instrument that was developed for evaluating the functional recovery of patients over 60 years of age who undergo surgical treatment due to hip fractures. The objective of this study was to make a thorough transcultural translation of this questionnaire, with adaptation to the individual and cultural traits of the Brazilian population. METHOD: This translation method consisted of initial translation, back translation, drafting of a consensual version and pretesting with comments invited. Subsequently, a final version was drawn up after making the necessary adjustments, without altering the semantics of the questions in the original text. RESULTS: The consensual version was applied to thirty patients over the age of 60 years who had undergone surgical treatment due to hip fractures. However, some difficulties in understanding some words and expressions were observed, and these were then replaced with terms that were more easily understood. After the final version had been drawn up, this was applied to the same patients and full understanding was achieved among some of them, without altering the semantics of the questions of the original text. CONCLUSION: The transcultural translation of the Hip Function Recovery Score will have an immediate impact on functional evaluations on patients over 60 years of age who underwent surgery due to hip fracture. It will subsequently be possible for other Brazilian scientific studies to use this questionnaire, which has been standardized and adapted to Brazilian culture, in order to make comparisons between results, thereby enriching Brazilian scientific production.

OBJETIVO: O questionário Hip Function Recovery Score consiste em um instrumento desenvolvido para avaliação da recuperação funcional de pacientes acima de 60 anos submetidos a tratamento cirúrgico devido a fraturas do quadril. O objetivo deste estudo foi fazer a tradução transcultural de forma criteriosa do questionário e adaptá-lo às características individuais e culturais da população brasileira. MÉTODO: Este método consiste em tradução inicial, retrotradução, elaboração de uma versão de consenso e pré-teste comentado com posterior elaboração de uma versão final após as alterações necessárias sem modificar a semântica das perguntas do texto original. RESULTADOS: A versão de consenso foi aplicada em 30 pacientes, acima de 60 anos, que foram submetidos a tratamento cirúrgico devido a fraturas do quadril. Foram observadas, entretanto, algumas dificuldades no entendimento de algumas palavras e expressões, as quais foram substituídas por termos de mais fácil entendimento. Após a elaboração da versão final, reaplicou-se essa versão aos mesmos pacientes e obteve-se um entendimento total. CONCLUSÃO: A tradução transcultural do questionário terá impacto imediato na avaliação funcional dos pacientes com mais de 60 anos operados devido a fraturas do quadril e, posteriormente, outros trabalhos nacionais podem usar esse questionário padronizado e adaptado à nossa cultura para comparação de resultados e enriquecer a produção científica do Brasil.

Condylar buttress plate for fixation of distal femur fracture: Functional and anatomical evaluation.

Background: Distal Femur fractures are one of the common fractures occurring in road traffic accidents. Various modalities are used for fracture of distal femur, one of them is condylar buttress plate. Various studies have claimed better results in surgical management of distal femur fracture. This study was planned to compare two treatment modalities for supracondylar and intercondylar fracture of the femur, open reduction and internal fixation with a condylar buttress plate. Aims & Objective: Objective of this study was to study the surgical technique for fixation of lower end femur fractures with condylar buttress plate and its functional and anatomical outcome. Materials and Methods: Total 30 patients above 18 years of age irrespective of gender, having fresh displaced and undisplaced fractures type A1, A2, A3, C1, C2,C3 and nonunion of distal femur fractures. Distal femur fracture was fixed with condylar buttress plate Results: A total of 30 cases were studied comprising 21 males (70%) and 9 females (30%) of which mean age is 37 years. Mean hospital stay was 35.8 days, out of 30 patient 11 patients developed some complication. 22 patients have good to excellent results as outcome. Conclusion: The Condylar Buttress Plate is an effective method for the treatment of Supracondylar and intercondylar fractures of the femur.

Propiedades psicométricas de una versión en castellano de la escala motor activity Log-30 en pacientes con extremidad superior parética por accidente cerebro vascular / Psychometric properties of a Spanish version of motor activity Log-30 in patients with hemiparetic upper extremity due to stroke

Introducción: Motor Activity Log (MAL) es una entrevista estructurada, que evalúa el uso del brazo parético en pacientes con Accidente Cerebro Vascular. MAL fue traducida al español y validada. Objetivo: Examinar la confiabilidad y validez de constructo entre MAL, Action Research Arm (ARA), edad, dolor y la escala Stroke Impact Scale 3.0 (SIS). Método: Fueron evaluados 40 pacientes del sistema público de salud. En la primera medición se aplicó una ficha clínica y demográfica, MAL-30 y ARA. Un mes después; en la segunda medición se aplicó MAL-30, ARA y SIS 3.0. Mediciones: la confiabilidad fue evaluada a través de la consistencia interna de los puntajes de cantidad y calidad de MAL-30, los puntajes de ARA y la subescala función de la mano de SIS 3.0. El grado de acuerdo entre las escalas de MAL se evaluó a través de r Pearson. La validez de constructo fue evaluada por correlación entre los puntajes de la primera y segunda medición de cantidad y calidad de MAL, ARA, edad, dolor y espasticidad. Así también, entre los puntajes de la segunda medición de MAL y función de la mano utilizando r Pearson y rho de Spearman. Resultados: MAL-30 mostró adecuada consistencia interna y estabilidad temporal. Además, de una apropiada validez de constructo correlacionando significativamente y en la dirección esperada con ARA, función de la mano, edad, dolor y espasticidad. Conclusiones: la evidencia indica que MAL-30 es un instrumento confiable y válido para evaluar el uso del brazo parético en pacientes de habla hispana.

Background: Motor Activity Log (MAL) a structured interview for stroke patients to assess the use of their paretic arm. MAL was translated and validated in Spanish. Objective: Examine the reliability and construct validity between MAL, Action Research Arm (ARA), age, pain and Stroke Impact Scale 3.0 (SIS). Methods: 40 patients from the Public Health System were evaluated. The first measurement in which clinical and socio demographic background, MAL-30 and ARA were applied. A month later; the second measurement was applied using MAL-30, ARA, and SIS 3.0. Outcome measures: The reliability was evaluated, as the internal consistency for scores of quantity and quality of movement, as well as for scores of ARA and hand function subscale SIS 3.0. The degree of agreement MAL scales, assessed through the Pearson r. Construct validity assessed by correlating scores of the first and second measurement of quantity and quality of MAL, ARA, age, pain and spasticity. As well as between the scores of the second measurement of MAL and hand function of SIS 3.0, using the Pearson r and Spearman rho. Results: The quantity and quality scores of MAL-30 showed adequate levels of both internal consistency and temporal stability. In addition to an appropriate construct validity by correlating, significantly and in the expected direction, with ARA and the hand function, as well as with age, pain and spasticity. Conclusions: The evidence indicates that MAL-30 is a reliable and valid instrument to evaluate the use of the paretic arm in Spanish language patients.

6MWT Predicts Survival Better Than CPET in Patients with Stable Cardiomyopathy.

Aims: The prognostic value of different clinical, echocardiographic and functional parameters was evaluated in clinically stable outpatients with heart failure due to idiopathic dilated cardiomyopathy (DCM). Study Design: Observational prospective study. Methodology: 56 patients suffering from idiopathic dilated cardiomyopathy in waiting list for heart transplantation (33 men and 23 women, mean age 56.4 years) and in clinical stable conditions for a minimum of 3 months underwent baseline clinical evaluation, echocardiogram, 6 minute walk test (6 MWT) and cardiopulmonary exercise test (CPET). They were followed for an average period of 26.5 months to assess eventfree survival (death, heart transplantation). Results: During follow-up period 23 patients died, 21 for cardiovascular causes. 4 patients underwent heart transplantation. Age and sex were not related to survival. We found a significant predictive value for 6MWTD (at 1 year event-free survival was 53% for a distance <300 m), but not for VO2 peak or respectively anaerobic threshold (AT). At multivariate analysis using Cox-stepwise regression model NYHA class, 6MWTD, left ventricular ejection fraction and left ventricular end diastolic diameter were independent prognostic markers of survival. Conclusion: An advanced NYHA class, a higher LVEDD and a distance of < 300m at 6MWT are useful prognostic markers of event free survival in outpatients with stable DCM while CPET was not.

Evaluación funcional de la vía aérea / Functional asessment of airway

Airway function study includes a variety of tests involving various sub-specialties of medicine and related professions. We describe the methods that assess: 1) upper airway (nose to larynx): rhinomanometry, acoustic rhinometry and nasopharingolaryngoscopy, 2) central airways (trachea and main bronchi): bronchoscopy, imaging study and Flow / Volume curve, 3) distal or peripheral airway: spirometry, bronchodilator response assessment, airway hyper responsiveness and measurement of airway resistance (plethysmography, interrupted resistence and impulse oscillometry).

El estudio de la función de la vía aérea abarca una gran variedad de exámenes que implican a diversas subespecialidades de la medicina y profesiones relacionadas. Se describen los métodos que evalúan: 1) vía aérea superior (nariz hasta laringe): rinomanometría, rinometría acústica y nasofarigolaringoscopía, 2) vía aérea central (tráquea y bronquios mayores): bronconcoscopia, estudio de imágenes y curva flujo/volumen, 3) vía aérea distalo periférica: espirometría, evaluación de respuesta a broncodilatador y de hiperreactividad bronquial y medición de la resistencia de la vía aérea (pletismografía, resistencia interrumpida y oscilometría de impulso).

Surface electromyography characteristic analysis of frozen shoulder in three-dimensional motion / 国际生物医学工程杂志

ObjectiveTo analyze characteristic changes of shoulder muscles by investigating surface electromyographic regularity changes before and after the treatment of Frozen shoulders. Methods7 cases of frozen shoulders were selected, surface electromyography (sEMG) before and after treatment were recorded by AMT-8 EMG recorder. The collected data was processed using MATLAB software integrated EMG (IEMG) value were obtained. Then the IEMG data were statistically analyzed using Stata11.0 software and compared. Results ①The differences of abduction deltoid and infraspinatus muscle IEMG values before and after treatment were statistically significant(P ＜0.05), while IEMG values changes of biceps, triceps, pectoralis major, latissimus dorsi and trapezius before and after treatment were not statistically significant (P＞0.05); changes of adduction IEMG values of all muscles were not statistically significant (P＞0.05). ②Changes of flexion IEMG values of biceps before and after treatment were statistically significant (P＜0.05), while IEMG values changes of pectoralis major, infraspinatus muscle, latissimus dorsi, trapezius, deltoid, triceps before and after treatment were not statistically significant (P＞0.05). Changes of extension IEMG values of triceps before and after treatment were statistically significant (P＜0.05), while those of pectoralis major, infraspinatus muscle, latissimus dorsi, trapezius, deltoid and biceps were not statistically significant (P＞0.05). ③IEMG values of all the muscles during external rotation, internal rotation before and after treatment IEMG were not significantly different. Conclusion①After treatment, the outreach functions of infraspinatus and deltoid muscles were improved, while adduction functions of all muscles were not improved. ②Flexion function of biceps was improved significantly after treatment as well as extension function of triceps.③Extemal rotation, internal rotation functions of all muscles were not improved significantly.

Análise funcional do comportamento na avaliação e terapia com crianças / Functional analysis of behavior in the assessment and therapy of children

Este artigo objetiva apresentar a importância da análise funcional do comportamento na avaliação e terapia comportamentais com crianças. Tomou parte um caso com oito anos e seis meses de idade, sexo feminino e dois anos de escolaridade. Sua mãe procurou atendimento com as descrições comportamentais da filha: desatenta, agitada, agressiva, desobediente e com dificuldades escolares. A avaliação funcional foi realizada em seis situações: terapeuta-cliente, terapeuta-mãe, terapeuta-pai, terapeuta-pais, terapeutatia e terapeuta-professora. Os principais procedimentos foram a observação do repertório comportamental da cliente, o relato verbal e a aplicação de instrumentos específicos. A análise funcional do comportamento foi promovida com base na formulação de hipóteses dos efeitos de mudanças ambientais nos comportamentos-queixa da cliente. Procedimentos de reforço verbal e generalizado foram utilizados para aumentar a autoestima e desenvolver um comportamento de melhor desempenho aritmético e acadêmico. Ambos os objetivos foram alcançados. Esse estudo de caso demonstrou que a análise funcional pode embasar processos de avaliação e psicoterapia infantil, tornando-os mais efetivos.

This article aims to demonstrate the importance of functional behavior analysis in behavioral evaluations and therapy involving children. A client took part who was eight years and six months old, female and with two years of schooling. Her mother sought assistance with the behavioral descriptions of her daughter: listless, agitated, aggressive, disobedient and with learning difficulties. The evaluation was conducted in six functional situations: therapist-client, therapist-mother, therapist-father, therapistboth parents, therapist-aunt and therapist-teacher. The main procedures involved the observation of the behavioral repertoire of the client, verbal account and the application of specific tools. The functional analysis of behavior was promoted based on the formulation of hypotheses of the effects of environmental changes on the client's complaint-behavior. Procedures of verbal and generalized reinforcement were used to increase selfesteem and develop a behavior that included better arithmetical and academic performance. Both goals were achieved. This case study demonstrated that functional analysis can be based on processes of evaluation and child psychotherapy, making them more effective.

Valores normativos e aptidão funcional em homens de 60 a 69 anos de idade / Normative values and functional fitness in 60-to-69 year-old men

O objetivo deste estudo foi desenvolver valores normativos para a aptidão funcional e o índice de aptidão funcional geral (IAFG) para homens de 60 a 69 anos. Foram avaliados 112 idosos residentes em Florianópolis/SC ou Rio Claro/SP, por meio da bateria de testes da AAHPERD, que realizavam atividade física sistematizada, supervisionada e regularmente, há pelo menos 6 meses. A bateria é composta por cinco testes que avaliama flexibilidade, coordenação, agilidade/equilíbrio dinâmico, força e capacidade aeróbia. Para a análise dos dados e construção dos valores normativos das aptidões funcionais e do IAFG, utilizou-se o cálculo de percentis. Foram utilizados como pontos de corte os percentis20, 40, 60 e 80 para gerar as classificações: muito fraco, fraco, regular, bom e muito bom, respectivamente. O desenvolvimento de valores normativos pode servir como referência aos profissionais, para que possam melhor avaliar, orientar e prescrever atividade físicapara homens idosos.

The objective of this study was to develop normative reference of functional fitness and an overall functional fitness index (OFFI) for 60- to 69-year-old men. A total of 112 oldermen living in Florianópolis/SC and Rio Claro/SP, who had been participating in structured and supervised physical activities on a regular basis for the past 6 months, were evaluated by the AAHPERD test battery. This battery consists of five tests that evaluate flexibility, coordination, balance and agility, muscle strength, and aerobic capacity. Percentile scores were calculated for the raw scores obtained in each test and the sum of percentiles was used as the OFFI. The 20th, 40th, 60th and 80th percentiles were taken as limits to classify the components and OFFI as very weak, weak, fair, good, and very good, respectively. The development of normative reference might be useful for professionals to improve the evaluation, supervision and prescription of physical activity to older men.